Polymorphism rs2476601 in the PTPN22 gene is associated with type 1 diabetes in children from the South Region of Brazil

Marciane Welter,Waldemar Volanski,Dayane Alberton,Suzana Nesi França,Geraldo Picheth,Fabiane Gomes de Moraes Rego

Gene（2018）

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摘要

•PTPN22 is the third major genetic locus that contributes to the risk of development of T1D.•PTPN22 is involved in the regulation of innate and adaptive immune responses.•R620W (rs2476601) is associated with increased risk for T1D.

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关键词

PTPN22,SNPs,Case-control study,Type 1 diabetes mellitus,Genetic variability

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