TREATMENT WITH TETRAHYDROBIOPTERIN ACCELERATES WHITE MATTER MATURATION IN A MOUSE MODEL OF PRENATAL HYPOXIA SIMULATING CONGENITAL HEART DISEASE

Jennifer Romanowicz,Ludmila Korotcova, Shruti D. Ramachandra,Paul D. Morton,Amrita Cheema,Vittorio Gallo,Richard A. Jonas,Nobuyuki Ishibashi

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2018）

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摘要

Reduced oxygen delivery in complex congenital heart disease (CHD) can cause delayed brain maturation and white matter (WM) injury during fetal life. Currently no treatment exists. Tetrahydrobiopterin (BH4) is a cofactor for neuronal nitric oxide synthase. BH4 availability is reduced upon nitric

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