123 Global Prevalence, Patient Profiles, and Health Outcomes of Erectile Dysfunction (ED) among 40-70 Year-old Men

ED prevalence and burden of illness in the literature can vary greatly in geography, time, and methodologies, which can be a limitation, particularly in cohorts of higher burden. This study provides an update on ED burden among older males across different geographies and prevalence with or without a common comorbidity, benign prostatic hyperplasia (BPH). Adult men (40-70 years old) were selected from 2015 National Health and Wellness Surveys (NHWS) in Brazil and China, and 2016 NHWS in France, Germany, Italy, Spain, UK, and US. ED assessment was based on any reported difficulty achieving/maintaining erection (past six months); patients were also flagged for BPH. ED prevalence was estimated with post-stratification sampling weights based on census data. SF-6D health utilities and work and activity impairment measures were included. Each country was compared with US via chi-square/one-way ANOVA for categorical/continuous variables. Italy had the highest ED prevalence (51.3%, 7.6M with BPH; 46.5%, 6.9M without BPH), followed by China (47.5%, 62.4M; 46.2%, 60.7M), France (46.3%, 6.7M; 44.6%, 6.4M), and US (45.7%, 27.4M; 41.7%, 25.0M). Brazil had the lowest prevalence (39.3%, 13.2M; 36.5%, 12.2M). In men with ED without BPH, diabetes and hypertension were most frequent in Germany (20.1% and 44.4%, respectively) and US (19.9% and 43.7%) and significantly less frequent elsewhere (China’s being lowest: 5.7% and 22.4%). Dyslipidemia and obesity were significantly more frequent in the US (41.0% and 39.7%, respectively) than elsewhere (China’s being lowest: 9.5% and 5.6%). Diagnosed depression was highest in UK (26.7%) and lowest in China (1.5%). UK had the highest absenteeism (11.5%) and activity impairment (33.8%). Presenteeism and overall work impairment were highest in Italy (27.5% and 30.3%, respectively) and UK (27.1% and 29.8%).