A Mouse Model of Recovery from Non-Ischemic Heart Failure

Although the concept of recovery in humans (through MCS devices) has been increasingly recognized, there is no established mouse model to study cardiac recovery from HF. We have previously created a non-ischemic mouse model of HF using C57 male mice, NaCl and L-NAME in drinking water and surgically-implanted angiotensin-II infusion pumps in a 5-week protocol.