MP44-05 COMORBIDITIES AFFECT THE HEALTH-RELATED QUALITY OF LIFE OF PATIENTS WITH UROLITHIASIS: CROSS-SECTIONAL ANALYSIS FROM THE NORTH AMERICAN STONE QUALITY OF LIFE CONSORTIUM

You have accessJournal of UrologyGeneral & Epidemiological Trends & Socioeconomics: Practice Patterns, Quality of Life & Shared Decision Making I1 Apr 2018MP44-05 COMORBIDITIES AFFECT THE HEALTH-RELATED QUALITY OF LIFE OF PATIENTS WITH UROLITHIASIS: CROSS-SECTIONAL ANALYSIS FROM THE NORTH AMERICAN STONE QUALITY OF LIFE CONSORTIUM Kristina L. Penniston, Shuang Li, Jodi A. Antonelli, Davis P. Viprakasit, Timothy D. Averch, Sri Sivalingam, Thomas Chi, Ben H. Chew, Vincent G. Bird, Vernon M. Pais, Jr., Necole M. Streeper, Jaime Landman, Roger L. Sur, and Stephen Y. Nakada Kristina L. PennistonKristina L. Penniston More articles by this author , Shuang LiShuang Li More articles by this author , Jodi A. AntonelliJodi A. Antonelli More articles by this author , Davis P. ViprakasitDavis P. Viprakasit More articles by this author , Timothy D. AverchTimothy D. Averch More articles by this author , Sri SivalingamSri Sivalingam More articles by this author , Thomas ChiThomas Chi More articles by this author , Ben H. ChewBen H. Chew More articles by this author , Vincent G. BirdVincent G. Bird More articles by this author , Vernon M. Pais, Jr.Vernon M. Pais, Jr. More articles by this author , Necole M. StreeperNecole M. Streeper More articles by this author , Jaime LandmanJaime Landman More articles by this author , Roger L. SurRoger L. Sur More articles by this author , and Stephen Y. NakadaStephen Y. Nakada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1424AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of this study was to evaluate the hypothesis that having certain comorbidities reduces patients′ stone-related quality of life. Patients from 11 urology sites across North America completed the Wisconsin Stone Quality of Life questionnaire (WISQOL), a stone-specific instrument designed to assess the health-related quality of life (HRQOL) of patients with urolithiasis. METHODS This cross-sectional study comprised 2,176 patients who completed the WISQOL and for whom comorbidities at the time of WISQOL completion were documented. Patient comorbidities were prospectively selected from a list of 24; those with prevalence ≥5% were included in the analyses. Hierarchical regression and MANOVA were performed to examine the relationship with HRQOL. RESULTS Patients were 51.5% men, 53.4±14.4 years old, and had a BMI at enrollment of 30.3±7.5 kg/m2. Comorbidities (prevalence) were: hypertension (36%), dyslipidemia (21%), depression/anxiety (20%), diabetes mellitus type 2/borderline-diabetes (DM/BDM; 16%), gastroesophageal reflux (13%), irritable/inflammatory/short bowel (IBS/SB; 7.4%), cardiovascular disease (7.3%), hypothyroidism (7.1%), osteoporosis/osteopenia (6.6%), gout (5.4%), and degenerative joint disease (5.1%). Nearly half (46.2%) had ≥2 of the 24 comorbidities of concern. Overall, the number of patients′ comorbidities did not correlate with total WISQOL score (R= -0.08), but patients with ≥2 comorbidities had significantly lower scores than those with ≤1 (P=0.001). DM/BDM, IBS/SB, and depression/anxiety were significantly inversely associated with patient HRQOL (P<0.035, MANOVA) when controlled for presence of a stone(s) or stone-related symptoms at time of WISQOL completion. Depression/anxiety without pharmacologic treatment was associated with lower HRQOL compared to patients without depression/anxiety (P<0.0001 for those with a stone and symptoms, MANOVA) and to patients with depression/anxiety but on pharmacologic treatment (P=0.014 for those with a stone, MANOVA). IBS/SB did not adversely influence patients′ HRQOL when they had no stone(s) or stone symptoms but did when patients reported having a current stone(s) and symptoms (P<0.0001 and P=0.003, MANOVA). CONCLUSIONS DM/BDM, IBS/SB, and depression/anxiety were significantly inversely associated with patients′ stone-related HRQOL. In patients with a stone(s) and stone-related symptoms, untreated depression/anxiety further reduced HRQOL. Efforts to treat or manage these comorbidities may enhance patients′ stone-related HRQOL and potentially improve traditional stone-related outcomes. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e589 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Kristina L. Penniston More articles by this author Shuang Li More articles by this author Jodi A. Antonelli More articles by this author Davis P. Viprakasit More articles by this author Timothy D. Averch More articles by this author Sri Sivalingam More articles by this author Thomas Chi More articles by this author Ben H. Chew More articles by this author Vincent G. Bird More articles by this author Vernon M. Pais, Jr. More articles by this author Necole M. Streeper More articles by this author Jaime Landman More articles by this author Roger L. Sur More articles by this author Stephen Y. Nakada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...