Synergistic cellular responses to heavy metal exposure: A minireview

Biochimica et Biophysica Acta (BBA) - General Subjects（2018）

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摘要

•Exposure to metals can activate both HSR and metal response.•Evidence suggests a direct interaction of HSF-1/HSE and MTF-1.•The interaction between metals and HSR may synergistically enhance tolerance to metals.•Metals can directly affect NF-κB signaling by regulating its upstream activators.

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关键词

MTF-1,MT,NF-κB,HSR,Zn,Cu,Fe,Cd,ROS,TNF-α,IL-6,PKC,JNK,PI3K,Pb,PP2A,IL1,IκB,IKK,NEMO,HSP,HSF-1,HSE,dHSE,pHSE,CdRE,GFP

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