Emotion Processing Abnormalities In Bipolar Disorder: An Fmri Study Using An Emotional Go/Nogo Task

Bipolar disorder (BD) is characterized by emotion processing deficits; however, their neural underpinnings are still poorly understood. We previously identified an emotion processing bias, measured by an affective go/nogo (AGNG) task, as a potential neurocognitive endophenotype in BD. Stable BD and their siblings had a response bias toward negative emotional stimuli compared with healthy controls (HC). We aimed to expand our prior finding by examining the neural underpinnings of this negative emotional bias. Specifically, we aimed to compare fMRI activity in frontolimbic areas during an AGNG task in BD and HC.