262. Human Dg-Seq Reveals Cell-Type-Specific Effectors of Schizophrenia Risk

The granule cell layer of the Dentate Gyrus (DG-GCL) is an unusually homogeneous cell population. Previous findings linking this important cell type to bipolar disorder and schizophrenia used animal models, induced pluripotent stem cell (iPSC), or low-resolution functional imaging. We therefore sought to isolate and characterize human DG-GCL neurons to better characterize their role in psychiatric disorders.