S86. Vesicular Monoamine Transporter (VMAT2) Binding in Platelets As a Biomarker for Severity of Major Depressive Disorder

Adrienne Hezghia,Megan Lee Fitzgerald, Benjamin I. Richter,Yolanda Mara Zafrina,Licinia Gananca,Anthony Tucker Valdes,Hanga Galfalvy,Maria Oquendo,J. John Mann,M. Elizabeth Sublette

Biological psychiatry（2018）

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摘要

Monoamine neurotransmission has been implicated in major depressive disorder (MDD). Vesicular monoamine transporter-2 (VMAT2) sequesters cytosolic monoamines inside presynaptic vesicles in neurons, as well as in platelets, which can be used as an accessible peripheral model.

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关键词

Major Depressive Disorder (MDD),Suicide,Mood Disorders,Platelets,VMAT2

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