Sa1597 - Upregulation of Mast Cell Related Genes in Irritable Bowel Syndrome

between fructose and lactose tests (all p<0.0001).The onsets of GI and CNS symptoms and of peak hydrogen and methane gas concentrations were markedly delayed and the durations of symptoms prolonged following lactose compared with fructose ingestion (figure).The two distinct symptom clusters identified by treelet transform analysis comprised a GI and a CNS cluster, which were identical following fructose and lactose, except that diarrhea was included only in the GI cluster for lactose.Conclusion: The temporal pattern and extent of microbiome metabolism of fructose and lactose clearly differed.These data suggest either different effects on GI transit, or in distribution or functional capacity of the microbiome metabolizing fructose and lactose.Differential effects of individual sugars in FGID are likely to be of clinical consequence and need to be examined further.