791 - Gastrointestinal Bacterial Pathogen Colonization and Risk for Subsequent Infection in the Intensive Care Unit

were absent from "aldo" distal colon.Conclusions: 1) AQP3 in concert with CaCC mediates CCH-induced water secretion; and 2) "aldo" inhibits CCH-induced water secretion by downregulating both AQP3 and CaCC expression.Speculation: As a corollary, we speculate that stimulation of colonic AQP3 and CaCC activities may be a novel approach to treat patients with chronic constipation.