Synthetic Access to Derivatized Mn-Pyane as a Redox-modulated Pool of SODm: Synthetic Access to Derivatized Mn-Pyane as a Redox-modulated Pool of SODm

In this work, four derivatives of the pentaazamacrocyclic Mn-pyane [pyane = trans-2,13-di meth yl-3,6,9,12,18-pentaaza-bicyclo[12.3.1]-octadeca-1(18),14,16-triene] complex were synthesized and characterized, carrying small substituents at the pyridine ring that allow fine-tuning of the manganese centered redox potential, without significant change to the overall complex arrangement that is cm- cial for a correct comparison regarding their superoxide dismutase mimetic (SODm) capabilities. The crystal structure of the seven-coordinate OMe-substituted Mn-pyane complex was obtained. The synthesized complexes will serve for future investigations related to an effect of complex redox potentials on their mechanistic behavior within SOD catalysis.