A multiphase model for exploring tumor cell migration driven by autologous chemotaxis

Chemical Engineering Science（2018）

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摘要

•A multiphase model is developed that can describe autologous chemotaxis consistent with in vitro experiments.•The role played by fluid-ECM, cell-ECM, and cell-fluid interaction forces are included.•The model illustrates how autologous chemotaxis can be used as a means for metastasis.

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关键词

Cell-migration,Multiphase flow,Interstitial fluid,Interstitial fluid pressure,Lymphatic flow,Vascular flow,Autologous chemotaxis,Chemokine,Protease

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