Intraarticular injection for rabbit knee osteoarthritis: effectiveness among hyaluronic acid, platelet-rich plasma, and mesenchymal stem cells

•Anterior cruciate ligament transection (ACLT) method is used for rabbit OA knee induction in the study.•Treatment effect among PRP, HA, HA+PRP, PRP+MSC and HA+MSC was evaluated after intraarticularly injection for 1 and 3 months.•A combination of HA and PRP was more effective than HA or PRP alone, but only in the medial compartment of the knee at month 1.•Results of macro- and microscopic observation and OARSI scores showed that PRP+MSC treatment could repair the OA knee for a longer time (3 months).