Core-shell-satellite microspheres-modified glass capillary for microsampling and ultrasensitive SERS spectroscopic detection of methotrexate in serum

Miao Chen, Jiading Tang,Wen Luo,Zhimin Zhang,Yuqiu Zhu,Ranhao Wang,Hua Yang,Xiaoqing Chen

Sensors and Actuators B: Chemical（2018）

引用 34|浏览17

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摘要

•1CSSM-modified glass capillaries were fabricated via a batch-fabrication process.•A novel SERS-enabled capillary platform for detection of methotrexate was developed.•Rapid detection of methotrexate in serum with response range: 0.1–110 nM.

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关键词

Surface-enhanced Raman scattering (SERS),Core-shell-satellite microspheres,Methotrexate,Glass capillary,Point-of-care diagnosis

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