Robustness Analysis of a Synthetic Translational Resource Allocation Controller

Alexander P. S. Darlington,Jongrae Kim,Declan G. Bates

IEEE Control Systems Letters（2019）

引用 5|浏览40

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摘要

Recent research in synthetic biology has highlighted the potential of translational resource allocation controllers to improve circuit modularity by dynamically allocating finite cellular resources in response to fluctuating circuit demands. The design of such controllers is complicated by the significant levels of parametric uncertainty that arise in their biological implementations. Tools from r...

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关键词

Proteins,Uncertainty,Resource management,Robustness,Integrated circuit modeling,Jacobian matrices,RNA

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