Interval Between Last Neoadjuvant Chemotherapy And Surgery And Between Surgery And First Adjuvant Chemotherapy In Ovarian Cancer Patients.

e17558Background: Neoadjuvant chemotherapy (NCT) is an option to treat ovarian cancer patients with bulky peritoneal disease who are not good candidates to complete primary debulking surgery. The best timing of NCT pause before surgery and restart after surgery is not clearly established. A recent paper suggested a longer interval between last NCT and first adjuvant chemotherapy (ACT) could have a negative prognostic impact. In this paper we evaluated the optimal timing between last NCT and surgery and between surgery and first ACT. Methods: We retrospectively evaluated ovarian cancer patients treated with NCT and debulking surgery at A.C.Camargo Cancer Center – Brazil from 2007 to 2017. At our institution, primary debulking surgery is the standard care, and patients are treated with NCT if there is a high risk for incomplete debulking in primary surgery or the patient have a poor performance status. Interval between last NCT and surgery and between surgery and first ACT were calculated and other clinical...