Mutational Burden And Activated T Cell Infiltration In Lung Squamous Cell Carcinomas With Dna Repair Mutations

Young Kwang Chae,Jonathan F. Anker,Nisha Mohindra,Jason Kaplan,Sunandana Chandra,Benedito A. Carneiro,Maria Matsangou,Victoria M. Villaflor,Leonidas C. Platanias,Francis J. Giles

JOURNAL OF CLINICAL ONCOLOGY（2016）

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摘要

3042Background: Mutations in DNA repair genes are common in cancer, and may induce a state of hypermutability. Importantly, mutational burden is linked to enhanced response to immunotherapies, as p...

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dna repair mutations,mutational burden,lung

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