Promoting Breast Cancer Screening After Multiplex Genetic Panel Testing (Mgpt) And Genetic Counseling

1581Background: Cancer screening guidelines recommend that germline carriers with a pathogenic variant (PV) in a breast cancer susceptibility gene undergo more intensive breast screening including breast magnetic resonance imaging (MRI). We assessed the impact of genetic counseling and MGPT on adherence to recommended screening. Methods: In a prospective cohort study of 2000 patients undergoing MGPT, patients completed self-adminstered questionnaires to document breast cancer screening within one year of testing. Patients were surveyed at 3, 6, and 12 months after genetic results disclosure. Multivariable logistic regression was used to analyze an association between MGPT result and breast MRI after adjusting for study center, personal history of breast cancer and personal history of breast surgery. Results: 2000 patients completed MGPT and 1532 (77%) completed at least one follow-up survey. 242 (12%) tested positive for at least 1 PV in any one of 25 (or 28) genes. MGPT identified a PV in the following i...