Cancer signaling pathways with a therapeutic approach: An overview in epigenetic regulations of cancer stem cells

•Bulk tumors can arise from a particular complex of cells and have a remarkable key role in carcinogenesis and tumorogenesis.•Epigenetic alterations including histone modifications and mainly DNA methylation are the most important agents in the differentiation process of stem cells in order to change them into different tissue subtypes.•Cancer stem cells can be employed for cancer treatment even in a more severe situation.•Deregulation of many different pathways comprising Sonic Hedgehog (SHH), WNT, Beta catenin and Notch can contribute to carcinogenesis particularly focusing to survival and maintenance of CSCs in therapeutic approach.