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Novel Approaches for Modeling C3 Glomerulopathy in Mouse and Rat

Kishor Devalaraja-Narashimha,Yifan Luo,Cong Huang,Theodore Kaplan,John O'Brien,Dara Lorn, Jeffery Lee,Scott MacDonnell,Rebecca Peyser,Gabor Halasz,Karoline Meagher,Sarah Casanova,John McWhirter, Jingjing Wang,Joseph Hickey, Michael Roos,William Poueymirou,Eric Chiao,Wojtek Auerbach,William Olson,Lynn Macdonald,Brian Zambrowicz,Andrew Murphy,George Yancopoulos,Lori Morton

Molecular immunology（2018）

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Abstract
Here we report for the first time that blending hexaamino-cyclo-triphosphazene with either poly-ε-caprolactone or poly-l-lactic acid enables the generation of blended electrospun scaffolds with enhanced bioactivities. These hexaamino-cyclo-triphosphazene-modified fibers significantly promote cell adhesion, spreading, metabolism, and proliferation. In addition to that we also report more efficient hexaamino-cyclo-triphosphazene synthesis with a higher yield and purity.
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Key words
C3 glomerulopathy,Novel mouse and rat models,Complement component 5,Complement component 3,Alternative pathway
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