2.54 Human Abuse Potential of Intravenous Serdexmethylphenidate (SDX), A Novel Prodrug of D-Methylphenidate, in Recreational Stimulant Abusers

Serdexmethylphenidate (SDX) is a prodrug of d-methylphenidate (d-MPH) in development for the treatment of ADHD. When taken orally as intended, SDX has an extended duration of action that is imparted by the gradual conversion of the prodrug to active d-MPH. Some individuals who abuse stimulants manipulate oral dosage forms to facilitate nonoral administration [eg, intranasal, intravenous (IV)]. The objective of this study was to examine the IV abuse potential of SDX relative to d-MPH HCl and placebo in recreational stimulant abusers.