Abstract 16735: Effect of Communicating Phenotypic and Genetic Risk of Coronary Heart Disease Alongside Web-based Lifestyle Advice - The Inform Randomized Clinical Trial

Introduction: Coronary heart disease (CHD) risk scores based on phenotypic information are routinely used in primary care. It has been suggested that genetics could be used to more precisely identify individuals at high risk of developing disease and to more effectively motivate individuals to change their lifestyle. However, there is a lack of adequately powered randomized trials using objective measures to evaluate the effect of provision of phenotypic and genetic CHD risk information on health behaviours. Hypothesis: We aimed to quantify the short-term (12 weeks) effects of provision of phenotypic and genetic CHD risk information, alongside lifestyle advice, on change in objectively-measured health behaviours and cardiovascular risk factors. Methods: In a parallel-group, open randomized trial, we allocated 956 male and female blood donors (mean (SD) age = 56.7 (8.8)) with no previous history of CHD to either no intervention (control group) or to one of three active intervention groups: i) web-based lif...