Chemokines sound the alarmin: The role of atypical chemokine in inflammation and cancer

•During inflammatory reactions, chemokines are tissue-derived signals serving as alarmins in case ot tissue damage.•Atypical chemokine receptors control chemokine bioavailability in tissues by presentation, transport and degradation processes.•Atypical chemokine receptors activities are essential for control of immune responses to tissue damage and in tumor biology.