Diuretic Response: Clinical and Hemodynamic Predictors and Relation to Clinical Outcome

•We investigated the clinical and hemodynamic profile that determines the response to loop diuretics in acute decompensated heart failure.•Independent predictors of urine output included loop diuretic dose, baseline and worsening renal function, lower baseline or fall in systolic blood pressure, fluid intake, male sex, and elevated right atrial pressure.•Among measures of loop diuretic responsiveness, net fluid loss was superior to urine output for the prediction of 6-month mortality.•Loop diuretic responsiveness is only partially explained by diuretic dose and is affected by other important variables, such as intravascular volume status and hemodynamics.