Trends In Complications And Outcomes Of Patients Undergoing Transfemoral Transcutaneous Aortic Valve Replacement: Experience From The Partner Continued Access Registry

Introduction: It is unknown if an evolution of case selection or accruing case experience over time has resulted in a change in the rates of complications and outcomes of patients undergoing Transfemoral (TF) Transcutaneous Aortic Valve Replacement (TAVR). Hypothesis: We hypothesized that such evolution may have occurred during the course of the PARTNER Continued Access Registry Methods: TF-TAVR patients enrolled in the PARTNER Continued Access (CA) Registry (n=1063, enrolled from 2009-2012 after completion of the PARTNER randomized trial) were divided into tertiles based upon enrollment date. The characteristics of patients enrolled and rates of adjudicated periprocedural and adverse events were compared over time. Results: There were no significant differences in sex, prevalence of NYHA III/IV symptoms, prior revascularization, pulmonary hypertension, renal disease or liver disease over time. There was an increase in the mean age of enrolled patients, but a decrease in the prevalence of porcelain aorta,...