EPHA4 regulates vascular smooth muscle cell contractility and is a sex-specific hypertension risk gene in individuals with type 2 diabetes.

Zeqin Zhang,Johanne Tremblay, John Raelson, Tamar Sofer,Lizhong Du, Qiang Fang,Maria Argos, Francois-Christophe Marois-Blanchet,Yu Wang, Lingling Yan,John Chalmers, Mark Woodward,Stephen Harrap,Pavel Hamet,Hongyu Luo,Jiangping Wu

Journal of hypertension（2019）

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摘要

EPHA4 appears to be a sex-specific hypertension risk gene in type 2 diabetic patients. Forward EPHA4 signalling reduces VSMC contractility, and estrogen is a modifier of this effect. The effect of EPHA4 on VSMCs contractility explains the association of EPHA4 gene with hypertension risks in female patients.

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