Elective Mechanical Circulatory Support in the Percutaneous Treatment of Patients With Combined Complex Coronary Artery Disease and Severe Aortic Valve Stenosis.

Objectives. One of the procedural concerns during percutaneous treatment of patients with concomitant coronary artery disease (CAD) and aortic valve stenosis (AS) is the risk of hemodynamic instability. In the present study, we assessed the safety and effectiveness of elective hemodynamic support with the Impella 2.5 system (Abiomed, Inc) in patients undergoing combined high-risk percutaneous coronary intervention (PCI) and balloon aortic valvuloplasty (BAV), as a bridge to transcatheter aortic valve replacement. Methods. Ten patients suffering from acute coronary syndrome (ACS) and severe AS were Included. In all patients, we first performed PCI with the hemodynamic support of the Impella 2.5 system, and then BAV, Results. The Impella catheter was successfully positioned In the left ventricle in all Instances. All cases were successful, without any intraprocedural complications, All patients were discharged without any major clinical events, Conclusions. These preliminary results suggest that elective use of the Impella 2.5 system is safe and effective when performing PCI and BAV In high-risk ACS patients suffering from concomitant severe CAD and AS.