An overview on the delivery of antitumor drug doxorubicin by carrier proteins

D. Agudelo,Gervais Bérubé,H.A. Tajmir-Riahi

International Journal of Biological Macromolecules（2016）

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摘要

⿢Structural aspects of doxorubicin conjugation with HSA, BSA and beta-LG are reviewed here.⿢HSA forms stronger drug conjugate than BSA and beta-LG.⿢Hydrophobicity plays a major role in DOX-protein conjugation.⿢H-bonding is the major contact in DOX-protein interactions.⿢Serum proteins can be used as DOX delivery system.

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关键词

DOX,HSA,BSA,b-LG,FTIR

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