5-Aza-CdR promotes partial MGMT demethylation and modifies expression of different genes in oral squamous cell carcinoma.

Guilherme C L S do Amaral,Aline C Planello,Gabriell Borgato,Dieila Giomo de Lima,Gustavo N Guimarães,Marcelo Rocha Marques,Ana Paula de Souza

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology（2019）

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摘要

We observed that 5-aza-CdR led to MGMT demethylation, upregulated the transcription of 3 important tumor suppressor genes, and promoted the downregulation of c-Myc.

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关键词

DNA Methylation

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