RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.

Robert A Baldock,Catherine A Pressimone,Jared M Baird, Anton Khodakov,Thong T Luong,McKenzie K Grundy,Chelsea M Smith,Yoav Karpenshif, Dominique S Bratton-Palmer,Rohit Prakash,Maria Jasin,Edwige B Garcin,Stéphanie Gon,Mauro Modesti,Kara A Bernstein

DNA Repair（2019）

引用 11|浏览16

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摘要

•Only RAD51D isoform 1 rescues HR-deficiency observed in RAD51D knock-out cell lines.•The RAD51D Walker A motif is important for its HR-function and interaction with XRCC2.•Phosphorylation near the Walker A motif is unlikely to regulate RAD51D function.

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关键词

Homologous recombination,RAD51 paralogs,RAD51D,XRCC2,Double-strand break repair,Walker A motif

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