Pro-apoptotic and Pro-Proliferation Functions of the JNK Pathway of Drosophila: Roles in Cell Competition, Tumorigenesis and Regeneration

The Jun N-terminal kinase (JNK) is amember of the mitogen-activated protein kinase family. It appears to be conserved in all animal species where it regulates important physiological functions involved in apoptosis, cell migration, cell proliferation and regeneration. In this review, we focus on the functions of JNK in Drosophila imaginal discs, where it has been reported that it can induce both cell death and cell proliferation. We discuss this apparent paradox in the light of recent findings and propose that the pro-apoptotic and the proproliferative functions are intrinsic properties of JNK activity. Whether one function or another is predominant depends on the cellular context.