Confining a Biocatalyst for Highly Efficient and Selective Synthesis of Carboxamide Derivatives under Continuous-Flow Conditions

The confinement of a biocatalyst designed to operate under continuous-flow conditions is a strategy developed by nature in order to achieve efficient reactions in biological media. Herein, we present a mimetic model that employs a confined lipase (CAL-B) in the production of several carboxamide derivatives from esters as precursors. The remarkable selectivity of such system is also described when α,β-unsatured carboxylic substrates are employed.