Esterase D enhances type I interferon signal transduction to suppress foot-and-mouth disease virus replication

Weiwei Li,Zixiang Zhu,Weijun Cao,Fan Yang,Xiangle Zhang,Dan Li,Keshan Zhang,Pengfei Li,Ruoqing Mao,Xiangtao Liu,Haixue Zheng

Molecular Immunology（2016）

引用 15|浏览15

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摘要

•FMDV infection induces the expression of esterase D (ESD) in PK-15 cells.•ESD restricts FMDV replication in PK-15 cells.•ESD enhances IFN-β signal transduction through promoting phosphorylation of IRF3.•ESD suppresses FMDV replication through upregulation of various interferon-stimulated genes (ISGs).

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关键词

Foot-and-mouth disease virus,Esterase D,IRF3,Interferon-stimulated genes,Antiviral response

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