Resveratrol affects DNA damage induced by ionizing radiation in human lymphocytes in vitro.

Emiliano Basso,Giulia Regazzo,Mario Fiore,Valentina Palma,Gianandrea Traversi,Antonella Testa,Francesca Degrassi,Renata Cozzi

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2016）

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摘要

•Resveratrol treatment does not induce DNA and chromosome damage in human lymphocytes in vitro.•40μM resveratrol increases ionizing radiation-induced dicentrics in human lymphocytes.•Resveratrol radiosensitizes human lymphocytes modifying the acetylation status of histones.

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关键词

Ionizing radiations resveratrol dicentrics ƴH2AX DNA damage repair HDAC activity

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