Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca 2+ channel–vesicle coupling

Mathias A Böhme, Christina Beis,Suneel Reddy-Alla,Eric Reynolds,Malou M Mampell,Andreas T Grasskamp,Janine Lützkendorf, Dominique Dufour Bergeron,Jan H Driller,Husam Babikir,Fabian Göttfert,Iain M Robinson,Cahir J O'Kane,Stefan W Hell,Markus C Wahl,Ulrich Stelzl,Bernhard Loll,Alexander M Walter,Stephan J Sigrist

Nature Neuroscience（2016）

引用 154|浏览10

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摘要

Coupling distances between synaptic vesicles and Ca 2+ channels determine the efficacy of neurotransmission. Böhme et al . find that presynaptic scaffold complexes spatiotemporally control Unc13 isoforms to establish two independent release pathways at subsynaptic active zones: Unc13B defines nascent, loosely coupled synapses whereas Unc13A facilitates release at mature synapses by tight coupling between Ca 2+ channels and synaptic vesicles.

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关键词

Synaptic vesicle exocytosis,Molecular neuroscience,Ion channels in the nervous system

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