ASSOCIATION STUDY OF SORL1 GENE SNP RS1133174 WITH THE RISK OF AMNESTIC MILD COGNITIVE IMPAIRMENT

To explore the association of sortilin-related receptor 1 (SORL1) gene single nucleotide polymorphism (SNP) rs1133174 with the risk of amnestic mild cognitive impairment (aMCI) in the Han Chinese population. We recruited 63 aMCI patients and 179 healthy controls and genotyped the SORL1 gene SNP rs1133174 using LDR-PCR method. The association between rs1133174 and the risk of aMCI was then analyzed. We found that the ‘G’ allele frequency in aMCI patients was significantly higher than that in healthy controls (OR = 2.221, 95% CI = 1.396-3.533, P = 0.0006). A logistic regression analysis further identified that the ‘G’ allele carriers had an increased risk compared with non-carriers (GG + GA vs. AA, OR =2.713, 95% CI = 1.495-4.918, P = 0.0005). Furthermore, a stratified analysis indicated that the SORL1 SNP rs1133174 might be an APOE ɛ4-independent risk factor. The SORL1 gene SNP rs1133174 may be significantly associated with the risk of aMCI in the Han Chinese population.