Macrophage-Derived Extracellular Vesicles Mediate A Long-Lasting Innate Immune Response Against Hepatitis C Virus

Background: Interferons play a pivotal role in the first line defense against viral infections. Macrophages are both important producers and responders to type I and II interferons and participate in antiviral immune responses. Yet, the precise role of macrophages in the immune response against hepatitis C virus (HCV) has not been entirely elucidated. In the present study, we therefore aim to further characterize mechanisms of macrophage-mediated antiviral immune responses against hepatitis C virus (HCV).