Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

Hamida Hammad,Matthias Vanderkerken,Philippe Pouliot,Kim Deswarte,Wendy Toussaint,Karl Vergote,Lana Vandersarren,Sophie Janssens,Ioanna Ramou,Savvas N Savvides,Jody J Haigh,Rudi Hendriks,Manfred Kopf,Katleen Craessaerts,Bart de Strooper,John F Kearney,Daniel H Conrad,Bart N Lambrecht

NATURE IMMUNOLOGY（2017）

引用 66|浏览49

暂无评分

摘要

The signaling receptor Notch is required for the generation of marginal zone B cells. Hammad and colleagues show that Notch signaling activates the kinase Taok3 and surface expression of the metalloproteinase ADAM10, which commits transitional B cells to the marginal zone B cell fate.

查看译文

关键词

Adaptive immunity,Marginal zone B cells,Biomedicine,general,Immunology,Infectious Diseases

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要