Bactericidal activity of sera from adolescents vaccinated with bivalent rLP2086 against meningococcal serogroup B outbreak strains from France.

Muhamed-Kheir Taha,Julio Cesar Hawkins,Paul Liberator,Ala-Eddine Deghmane,Lubomira Andrew,Li Hao,Thomas R Jones,Lisa K McNeil,Robert E O'Neill,John L Perez,Kathrin U Jansen,Annaliesa S Anderson

Vaccine（2017）

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摘要

•French MnB outbreak strains were characterized by WGS and FHbp surface expression.•Bactericidal activity of sera from bivalent rLP2086 vaccinees was evaluated.•MnB outbreak strains expressed vaccine-heterologous FHbp variants.•Response rates after vaccine dose 3 were ⩾73% against all strains (range, 73–100%).•Bivalent rLP2086 vaccination elicits broad protection against MnB outbreak strains.

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关键词

Factor H binding protein,Invasive meningococcal disease,Neisseria meningitidis serogroup B,Outbreak,Bivalent rLP2086,MenB-FHbp

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