Integrating Molecular Genetic And Gene Expression Profiling Allows Stratification Of Ultra-High Risk Myeloma

A significant proportion of myeloma patients relapse early and show short survival. Identifying these high risk patients at diagnosis enable stratified treatment approaches. Using two validated molecular approaches for risk prediction, molecular genetic profiling and gene expression profiling (GEP), we analysed two large multicentric UK National trials to define a category of ultra-high risk patients with significantly worse survival.