The functional roles of PML nuclear bodies in genome maintenance

Hae Ryung Chang, Anudari Munkhjargal, Myung-Jin Kim,Seon Young Park,Eunyoung Jung, Jae-Ha Ryu,Young Yang, Jong-Seok Lim,Yonghwan Kim

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2018）

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摘要

•Promyelocytic leukemia nuclear bodies are membraneless substructures of the nucleus.•SUMOylation is for PML, determining nuclear body formation as well as degradation.•There are permanent as well as transient interaction partners.•PML-NBs play a role in pathways involved in genome maintenance.

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关键词

PML-NB,DSBs,HR,APL,ALT,APB

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