ERECTILE DYSFUNCTION PREVALENCE, PATIENT CHARACTERISTICS, AND HEALTH OUTCOMES GLOBALLY

Erectile dysfunction (ED) global rates can vary across methods, locales, and/or time periods. This study updates reported ED prevalence and respective patient profiles in countries globally that previously demonstrated high ED burden. United States (US), France (FR), Germany (GE), Italy (IT), Spain (SP), UK, Brazil (BR), and China (CH) data were analyzed for adult men (18+ years) in National Health and Wellness Surveys in 2016. ED was defined as any self-reported difficulty achieving/maintaining erection (past six months). ED prevalence (with/without BPH) was estimated via census-informed post-stratification sampling weights. Health outcomes included SF-6D utility scores and Work Productivity and Activity Impairment. Comparisons between US and each country utilized chi-square/t tests for categorical/continuous variables. IT had the highest ED prevalence (46.9%, 11.6 M including BPH; 42.5%, 10.5M without BPH), followed by GE (42.0%, 13.9M; 39.1%, 12.9M), CH (41.8%, 98.2M; 41.0%, 96.2M), and FR (41.3%, 10.4M; 39.9%, 10.0M). BR had the lowest rates (33.2%, 23.0M; 31.5%, 21.8M). In men with ED without BPH, age was higher in US (52.4 years old) and EU (range: 53.5 [UK] to 56.5 [FR]) than in BR (43.8) and CH (45.6). Diabetes and hypertension were significantly more frequent in GE (18.8% and 40.9%, respectively) and less frequent elsewhere (CH’s being lowest: 4.4% and 17.0%). Dyslipidemia was more frequent in US (34.9%) than elsewhere (CH’s being the lowest: 7.2%). Obesity patterns mirrored these three risk factors. Diagnosed depression was highest in UK (21.4%) and lowest in CH (1.9%). Health utilities were significantly lower in CH (0.665) FR (0.674), IT (0.668), and UK (0.676) (vs. US). UK had the highest absenteeism (15.0%), presenteeism (34.7%), overall work impairment (38.8%), and activity impairment (36.0%).