Developmental neurogenesis in mouse and Xenopus is impaired in the absence of Nosip.

Meike Hoffmeister,Julia Krieg,Alexander Ehrke,Franziska A Seigfried,Lisa Wischmann,Petra Dietmann,Susanne J Kühl,Stefanie Oess

Developmental Biology（2017）

引用 10|浏览8

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摘要

•Nosip is required for brain development in mouse and Xenopus.•The loss of Nosip impairs primary neurogenesis.•Nosip has a cell autonomous function in neural stem and progenitor cells (NSPCs).•The loss of Nosip induces alterations of the proteome composition of NSPCs.•Nosip functions upstream of retinol binding protein 1.

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关键词

Brain development,Knockout mouse,Neurospheres,Neural stem and progenitor cells,Proteomics, Xenopus laevis

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