Only SETBP1 hotspot mutations are associated with refractory disease in myeloid malignancies.
Journal of cancer research and clinical oncology(2017)
摘要
Patients with SETBP1 hotspot mutations suffered from aggressive disease with rapid evolution and inferior overall survival. Patients with SETBP1 non-hotspot mutations had less aggressive disease and a more favorable prognosis. Diagnostic screens for SETBP1 hotspot mutations may help identifying this dismal patient group and treat them in multicenter clinical studies.
更多查看译文
关键词
SETBP1 hotspot mutations,sAML,MDS/MPN,Leukemia-associated genes,Myeloid malignancies
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要