Preparation and Characterization of Novel Brain Targeting Magnetic Nanoparticles Modified with Ascorbic Acid

Magnetic targeting, which utilizes a magneticfield to specifically deliver therapeutic agents to the targeted regions, can greatly improve the treatment eficiency. Herein, ibuprofen-loaded brain targeting magnetic nanoparticles (AA-Ibu-PEG-DA@MNPs) modified with ascorbic acid (AA) for central nervous system(CNS) drug delivery was designed and synthesized in order to effectively deliver ibuprofen to the brain through Nathorn-dependent vitamin C transporter 2 (SVCT2) and glucose transporter 1 (GLUT1). The brain targeting magnetic nanoparticles, AA-Ibu-PEGDA@MNPs, have a particle size of 82.5 nm, 2% drug loading capacity and limited cytotoxicity against bEnd. 3 cells. What's more, the nanoparticles maintained the magnetic property with a saturation magnetization level at 52.17 emu/g and could release ibuprofen when incubated in different mediums, including various buffers, mice plasma and brain homogenate. The results indicate that the magnetic nanoparticles may have the potential to be a promising approach to selectively deliver drugs into the brain. This study may be conducive to the field of CNS drugs delivery.