Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition.

Cecily G Swinford,Shannon L Risacher,Arnaud Charil,Adam J Schwarz,Andrew J Saykin

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring（2018）

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摘要

•Both self– and informant memory concerns are associated with tau aggregation in at-risk adults.•Self-concerns are more associated with frontal tau compared to a parietal pattern for informant concerns.•This pattern is strongest in amyloid-positive participants.

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关键词

Significant memory concern,SMC,Subjective cognitive decline,SCD,Early mild cognitive impairment,EMCI,Neuroimaging,AV1451,Tau PET,Alzheimer's disease neuroimaging initiative,ADNI

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