Evaluation on the persistence of anti-HPV immune responses to the quadrivalent HPV vaccine in Chinese females and males: Up to 3.5 years of follow-up.

•The immune responses to qHPV vaccine in Chinese subjects at month 42 following vaccination were investigated.•Two immunoassays were used, cLIA and IgG LIA.•The results of this study were similar to those observed in the global studies. The seropositivity of anti-HPV 6, 11, 16 remained high with both the cLIA and IgG LIA. For HPV 18, the seropositivity rate with the IgG LIA was higher than that with the cLIA.•Administration of a 3-dose regimen of qHPV vaccine induces durable high anti-HPV 6, -11, -16 and -18 responses among Chinese subjects for at least 3.5 years after vaccination.•IgG LIA, a more sensitive assay than cLIA, which measures a broader antibody profile, could be more suitable for evaluation of the vaccine-induced immune response over time.