90. Computational Modeling of Topographic Variation in Microcircuitry Across Human Cortex: Toward Linking Molecular Alterations with Neuroimaging Biomarkers

Neuroimaging biomarkers for neuropsychiatric disorders and pharmacology exhibit spatial topographies, i.e., structured patterns across brain regions. A key computational challenge is to understand how such neuroimaging patterns emerge from underlying alterations in microcircuit function. Furthermore, development of pharmacological therapeutics may benefit from linking macro-circuit characterizations of neurobehavioral processes and pathologies to heterogeneous topographies of drug targets; this circuit-based approach can evaluate systemic pharmacological effects on "on-target" vs. “off-target” brain regions.