Shiga toxin 2a binds antithrombin and heparin, but does not directly activate platelets.

Ludwig Knabl,Michael Berktold,Osama A Hamad,Karin Fromell,Sneha Chatterjee,Cornelia Speth,Heribert Talasz, Katharina Lindner,Martin Hermann,Kristina Nilsson-Ekdahl,Bo Nilsson,Werner Streif,Judith Martini,Reinhard Würzner,Dorothea Orth-Höller

International Journal of Medical Microbiology（2018）

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摘要

Escherichia coli-induced hemolytic uremic syndrome (eHUS) is a life-threatening complication of infection with Shiga toxin (Stx), in particular Stx2a-producing Escherichia coli. Enhanced coagulation activation with formation of microthrombi seems to be a key event in development of eHUS. Platelet activation has been postulated as a possible, but controversially debated mechanism.

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eHUS,Stx,EHEC,AT,AKI,t-PA antigen,PAI-1,TF,vWF,NOACs,PRP,APC,PE,LTA,ROTEM®,MFI,CT,SAP,QCM-D,PAV,CHC

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